2. Natural Products
  3. Alkaloids
  4. Pyrrolizidine Alkaloids

Pyrrolizidine Alkaloids

Pyrrolizidine Alkaloids (8):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N9279
    Dehydromonocrotaline 23291-96-5
    Dehydromonocrotaline is a mitochondrial respiratory chain complex I NADH oxidase inhibitor, with a IC50 of 62.06 μM and a Ki of 8.1 μM in rats. Dehydromonocrotaline exerts non-competitive inhibitory effects by modifying cysteine thiol groups on complex I, and does not bind to the NADH-binding site. Dehydromonocrotaline dissipates mitochondrial membrane potential and reduces ATP levels. Dehydromonocrotaline can be used in studies related to hepatotoxicity, pulmonary hypertension and liver tumors.
    Dehydromonocrotaline
  • HY-101245
    Pilsicainide hydrochloride 88069-49-2 99.94%
    Pilsicainide hydrochloride (SUN-1165) is an orally active sodium channel blocker and potent class Ic antiarrhythmic agent.
    Pilsicainide hydrochloride
  • HY-N3198
    (R)-Sophoramine 52932-74-8
    (R)-Sophoramine ((R)-(-)-Sophoramine) is a natural alkaloid.
    (R)-Sophoramine
  • HY-N16478
    Echihumiline 174285-73-5
    Echihumiline is an alkaloid targeting hepatic cytochrome P450 enzymes (CYP450). Echihumiline induces DNA cross-linking and oxidative stress in hepatocytes, leading to liver necrosis and fibrosis. Echihumiline is promising for research of liver diseases.
    Echihumiline
  • HY-N16470
    Echiumine 633-16-9
    Echiumine, a pyrrolizidine alkaloid, is a major dehydropyrrolizidine metabolite of Echium plantagineum. Echiumine has significant hepatotoxic activity and can persist intact from honey through to the resulting mead.
    Echiumine
  • HY-136486
    Lasiocarpine N-oxide 127-30-0
    Lasiocarpine N-oxide is a natural compound with antitumor activity.
    Lasiocarpine N-oxide
  • HY-N17822
    9-Angeloylretronecine 6922-62-9
    9-Angeloylretronecine is a pyrrolizidine alkaloid compound. 9-Angeloylretronecine can be used in natural product chemistry, plant secondary metabolites, and research on active ingredients of Boraginaceae plants. 9-Angeloylretronecine can be extracted from the whole plant methanol extract of Echium glomeratum (a plant of the Boraginaceae family).
    9-Angeloylretronecine
  • HY-W707957
    Intermedine N-oxide 95462-14-9
    Intermedine N-oxide is a pyrrolizidine alkaloid indicine that can be found in Crotalaria spectabilis. Intermedine N-oxide shows anticancer activity.
    Intermedine N-oxide